RFA:CA-03-002: Network for translational research: Optical imaging

In vivo molecular imaging for translational research

In vivo imaging has been playing an important role in diagnosing diseases and monitoring treatment. Recently, it is widening its field through revealing molecular events in cells and tissues. In vivo molecular imaging is useful not only for clinical studies but also for developing new drugs and new treatment modalities. Preclinical molecular imaging using animals such as mice shows biodistribut...

Developmental imaging genetics: challenges and promises for translational research.

Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework. Herein, we begin by outlining an experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics. We ...

In Vivo Cellular Imaging for Translational Medical Research.

Personalized treatment using stem, modified or genetically engineered, cells is becoming a reality in the field of medicine, in which allogenic or autologous cells can be used for treatment and possibly for early diagnosis of diseases. Hematopoietic, stromal and organ specific stem cells are under evaluation for cell-based therapies for cardiac, neurological, autoimmune and other disorders. Cyt...

Image Analysis Challenges in Translational Molecular Imaging Research

Translational molecular imaging for cancer

Although most clinical diagnostic imaging studies employ anatomic techniques such as computed tomography (CT) and magnetic resonance (MR) imaging, much of radiology research currently focuses on adapting these conventional methods to physiologic imaging as well as on introducing new techniques and probes for studying processes at the cellular and molecular levels in vivo, i.e. molecular imaging...